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hrp0097rfc3.3 | Fat, metabolism and obesity 1 | ESPE2023

Early Corneal Nerve Loss in Children with Melanocortin 4 Receptor (MC4R) Gene Mutation Related Obesity

Gad Hoda , Dauleh Hajar , Pasha Maheen , Omer Idris , Al-Barazenji Tara , Alshafai Mashael , A. Hendaus Mohamed , A. Malik Rayaz , Hussain Khalid

Background: Obesity is highly prevalent worldwide, particularly in the MENA region. Whilst simple obesity has a variable genetic and environmental basis, syndromic and non-syndromic monogenic obesity has a strong genetic component. Melanocortin 4 receptor (MC4R) mutations are the commonest cause of monogenic obesity. MC4R also regulates neuropathic pain pathways via JNK signaling after nerve injury.Methods: Five children...

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hrp0097fc3.5 | Fat, metabolism and obesity 1 | ESPE2023

Early corneal nerve loss in children with obesity and type 2 diabetes

Gad Hoda , Dauleh Hajar , Chirayath Shiga , Pasha Maheen , Haris Basma , Amin Rasha , Afyouni Houda , Petrovski Goran , Shehzad Saira , Khalifa Amel , Mohammed Ahmed Elwaseila , Mohamadsalih Ghassan , Campbell Judith , Jolkka Sari , Biglang-awa Roshirl , Cuatrona Erlinda , Inso Gina , Razon Gerald , A. Hendaus Mohamed , Elgassim Einas , N. Petropoulos Ioannis , Ponirakis Georgios , A. Malik Rayaz , Hussain Khalid

Background: Childhood obesity is highly prevalent in the MENA region and may be associated with sub-clinical neuropathy.Methods: Children with obesity with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and Type 2 diabetes Mellitus (T2DM) and healthy controls (HC) underwent body composition analysis, assessment of vibration perception threshold (VPT), monofilament sensitivity and corneal confocal micros...

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ESPE Abstracts

Early Corneal Nerve Loss in Children with Melanocortin 4 Receptor (MC4R) Gene Mutation Related Obesity

Early corneal nerve loss in children with obesity and type 2 diabetes

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